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ALLOSE AND MANNOSE:
MORE INGREDIENTS FROM BONUMOSE'S TECHNOLOGY PLATFORM
 
Bonumose has again extended its enzymatic technology platform for the production of affordable rare sugars and other ingredients. Similar to our tagatose and allulose enzymatic pathways, we successfully developed novel pathways for producing affordable allose and mannose. We filed our new patent applications today.
 
Allose

Allose is a low-glycemic, low-calorie sugar that has 70%-80% the sweetness of sucrose. It is a naturally-occurring monosaccharide that is present in only small amounts in specific shrubs and algae. Like allulose, allose is absorbed in the small intestine and fully excreted in urine. Allose boasts several potential health benefits including anti-oxidative, anti-hypertensive, anti-inflammatory, anti-tumor, and anti-cancer activities. It also has similar functionality to sucrose in foods and beverages. As such, allose has a variety of potential applications for foods and beverages. However, due to allose’s high selling prices, its use as a sweetener has been limited.
 
The standard industry process for producing allose involves enzymatic isomerization of high-cost allulose (aka psicose). This method suffers because of higher feedstock cost, the costly separation of allose from allulose/psicose, and relatively low product yields.
 
Like with Bonumose’s novel pathways for affordable tagatose and allulose/psicose, our allose process starts with low-cost commodity feedstock, does not require costly separations of intermediates, and produces high yields. Manufacturing cost savings will be comparable to the 80% cost savings from our novel enzymatic pathways for tagatose and allulose/psicose.

Bonumose will be scaling-up the allose process in tandem with scale-up of tagatose and other ingredients, and will be evaluating opportunities with strategic partners for allose commercialization.
 
Mannose

Mannose is a mildly sweet, naturally-occurring monosaccharide that is found in many fruits, vegetables, plant materials, and even the human body. Mannose boasts multiple health benefits, and has applications in pharma, dietary supplements, and personal care. For example, mannose can be used to treat urinary tract infections, as well as carbohydrate-deficient glycoprotein syndrome type 1b. Furthermore, mannose is a verified prebiotic, does not raise blood glucose levels, and shows anti-inflammatory properties. Additionally, it widely used as an auxiliary moisturizing agent for skin-care products. Mannose also has agricultural applications because it is effective against some plant pathogens.
 
The standard industry process for producing mannose involves extraction from plants. Common methods include acid hydrolysis, thermal hydrolysis, enzymatic hydrolysis, microbial fermentation hydrolysis, and mixtures thereof. Less common methods include chemical and biological transformations. In general, these methods suffer from harsh conditions, high capital expenditures, higher feedstock cost, costly separation of mannose from isomerization reactions, and relatively low product yields.

Like with Bonumose’s other novel enzymatic pathways, our mannose process starts with low-cost commodity feedstock, does not require costly separations of intermediates, and produces high yields. Manufacturing cost savings will be comparable to the cost savings from our tagatose and other processes.

Bonumose will be scaling-up the mannose process in tandem with scale-up of tagatose and other ingredients, and will be evaluating opportunities with strategic partners for mannose commercialization.
 
Bonumose Biochem LLC
 
Bonumose is a start-up food ingredient development, manufacturing, distribution and licensing company. Bonumose’s first rare sugar breakthrough was for the production of tagatose from starch and starch derivatives. Tagatose is a naturally-occurring, fiber-like sugar that is low glycemic, low calorie, safe for teeth, and a prebiotic, while being 92% as sweet as sucrose and fully functional in foods. Compared to standard tagatose production processes, Bonumose’s process uses lower cost feedstock, has lower cost processing steps, and achieves extremely high yields (90%). As a result, Bonumose’s tagatose can be sold at market distributing price points, making it affordable for widespread use in foods, beverages, and supplements. Third-party projections suggest tagatose could be a blockbuster ingredient, replacing a double-digit percentage of global sucrose consumption. Broad adoption of Bonumose’s affordable tagatose would have a profound positive impact on public health (diabetes, obesity, etc.), and this is a big part of Bonumose's raison d'être.
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