RESCEU’s clinical studies have started, with the aim of gathering data and addressing knowledge gaps on the impact of RSV infections. The investigation is building on the knowledge of a varied team of partners from universities and public health institutions, and includes 3 cohort studies on vulnerable populations (infants, older adults, COPD subjects) and one case-control study on infants after RSV infection. 

The first symptomatic participants were tested and visited for Respiratory Syncytial Virus in the 3 mentioned clinical cohort studies. As the RSV season had not yet started, all tested patients were still RSV negative: we can expect that first RSV diagnosis and therefore more exhaustive results will be available only with the beginning of RSV season.

WP2 will be holding a face to face meeting on the 23rd of January 2018 in Amsterdam to discuss the analysis plans for Task 2.1 “National and regional routine health service data”. The meeting will be attended by around 20 people ranging from RESCEU academic partners, EFPIA companies and Affiliated Partners. It aims to review the data availability for each partner, to discuss and agree the analysis plan and coding definitions and to work on the timescales for analysis for 2018. More information on the outcomes of the meeting will be provided on the next issue of the RESCEU newsletter and on the RESCEU website.

Registration is now open for the RESCEU 2nd General Assembly that will take place in Oxford on June 21st-22nd 2018. On this occasion, the meeting will be hosted by University of Oxford and it will be attended by the RESCEU’s Scientific Advisory Group, Ethics Advisory Committee and Patient Advisory Board.
 
There will also be WorkPackage pre-meetings on June 20th:

• WP1: Systematic literature review of RSV and current estimates of burden disease
• WP2: Consolidation of health care systems data
• WP3: Retrospective resource use analyses from existing databases/networks
• WP4&5: Prospective data collection and presumed risk factors and biomarkers for RSV-related severe disease and related sequelae
• WP6: Project management and outreach to stakeholders

 
For more information about the registration please send an email to Núria Febrer (nfebrer@synapse-managers.com) and Anna Beltrami (abeltrami@synapse-managers.com).

October 2017

Pre-F-Stabilized Rsv Vaccine, A New Vaccine On The Horizon?

Liu X, Liang B, Ngwuta J, Liu X, Surman S, Lingemann M, Kwong PD, Graham BS, Collins PL, Munir S. Attenuated human parainfluenza virus type 1 (HPIV1) expressing the respiratory syncytial virus (RSV) fusion F glycoprotein from an added gene: effects of pre-fusion stabilization and packaging of RSV F. Journal of Virology, November 2017, vol. 91 no. 22 e01101-17 Available from: doi: 10.1128/JVI.01101-17

Summary

RSV vaccine development has come across many difficulties, with the instability of the pre-fusion RSV F protein being one of them. Xiang Liu and colleagues offer a potential solution to this problem by developing a pre-F-stabilized RSV vaccine based on an attenuated HPIV1 vector. The benefit of such a vaccine is that it specifically increases the immune response against the most effective RSV-neutralization epitopes, while the HPIV1 vector provides immunization against HPIV1. The authors developed four HPIV1 vectors. In hamsters, all of the vectors induced detectable RSV-neutralizing serum antibodies, but only the F1 vector was immunogenic for both RSV and HPIV1. It induced complement-independent high-quality RSV-neutralizing antibodies at titers similar to those of wild type RSV and provided protection against RSV infection.
This study describes a novel vector-based vaccine inducing robust protection against RSV, by developing immunity against the pre-fusion conformation of the RSV F glycoprotein.
This review was written by drs. Sjanna Besteman

Full article on PubMed.

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October 2017
The first large case series of in-hospital RSV deaths

Scheltema NM, Gentile A, Lucion F, Nokes DJ, Munywoki PK, Madhi SA, Groome MJ, Cohen C, Moyes J, Thorburn K, Thamthitiwat S, Oshitani H, Lupisan SP, Gordon A, Sanchez JF, O’Brien KL, on behalf of the PERCH Study Group, Gessner BD, Sutanto A, Mejias A, Ramilo O, Khuri-Bulos N, Halasa N, de-Paris F, Rosane Pires M, Spaeder MC, Paes BA, Simoes EAF, Leung TF, da Costa Oliveira MT, de Freitas Lazaro Emediato CC, Bassat Q, Butt W, Chi H, Aamir UB, Ali A, Lucero MG, Fasce RA, Lopez O, Rath BA, Polack FP, Papenburg J, Roglić S, Ito H, Goka EA, Grobbee DE, Nair H, Bont LJ. Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series. Lancet Glob Health. 2017; 5: e984–91. Available from: doi: 10.1016/S2214-109X(17)30344-3 and doi: 10.1016/S2214-109X(17)30382-0 [errata corrige].

Summary

This is the first large descriptive study (case series) reporting 358 in-hospital deaths in children with community-acquired RSV infection. The study was conducted by Scheltema and colleagues using individual case records from hospitals. Nearly one third of children studied were from low income or lower middle income countries with high RSV-related mortality. A substantial proportion of children (28% in low and lower middle income, 47% in upper middle income and 70% in high income countries) had comorbidities. In low and middle income countries (LMICs), most children who died with RSV infection were aged younger than 6 months thus reinforcing the need to immunize children in this vulnerable age group. As the majority of the RSV related deaths in children occur outside hospitals, this study represents a small proportion of all RSV related deaths worldwide. Data on comorbidities and prematurity were missing for around one third of the children studied, mainly in LMICs. The results therefore need to be interpreted with caution.

Full Article on The Lancet Global Health website.

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September 2017

C-reactive protein differentiates RSV from bacterial infection

Higdon MM, Le T, O’Brien KL, Murdoch DR, Prosperi C, Baggett HC, Brooks WA, Feikin DR, Hammitt LL, Howie SRC, Kotloff KL, Levine OS, Scott JAG, Thea DM, Awori JO, Baillie VL, Cascio S, Chuananon S, DeLuca AN, Driscoll AJ, Ebruke BE, Endtz HP, Kaewpan A, Kahn G, Karani A, Karron RA, Moore DP, Park DE, Rahman MZ, Salaudeen R, Seidenberg P, Somwe SW, Sylla M, Tapia MD, Zeger SL, Knoll MD, Madhi SA; for the PERCH Study Group. Association of C-Reactive Protein with Bacterial and Respiratory Syncytial Virus–Associated Pneumonia Among Children Aged <5 Years in the PERCH Study. Clinical Infectious Diseases. 2017 Jun 15; Suppl 3(64): S378-386. Available from: doi: 10.1093/cid/cix150.

Summary

As part of the Pneumonia Etiology Research in Child Health (PERCH) multi centre case control study, Higdon and colleagues evaluated the sensitivity and specificity of C-reactive protein (CRP) for differentiating RSV and bacterial pneumonia. The comparison groups included “confirmed” bacterial pneumonia (positive blood / pleural fluid culture; or positive lung aspirate or PCR) and PCR confirmed RSV pneumonia. They observed that elevated CRP was positively associated with confirmed bacterial pneumonia and negatively associated with RSV pneumonia, with a sensitivity (77%) and specificity (82%) at a cut-point of 37.1 mg/L. They suggest that CRP could be useful to distinguish bacterial from RSV pneumonia. However, it was acknowledged that the cut-point varied by demographic and clinical factors, and might not be representative of other settings or other respiratory viral-associated pneumonia. Therefore, CRP should be complemented with other pathogen specific diagnostic tools to increase the performance.

Full Article on PubMed.

INTERNATIONAL SOCIETY FOR INFLUENZA AND OTHER RESPIRATORY VIRUS DISEASES, 2ND INTERNATIONAL MEETING ON RESPIRATORY PATHOGENS 2018
This meeting will focus on addressing these gaps through the sharing of recent advances in epidemiology, immunology, diagnostics, vaccines and therapeutics and clinical management. It will bring together clinicians, public health professionals, scientists, and policy makers to learn about respiratory pathogens, and discuss what are the next steps in reducing the burden of these diseases through research and policy initiatives. This includes specific sessions devoted to providing updates for policy makers to increase their understanding on respiratory diseases and to allow for better research-policy interactions that will accelerate translational research.
7th - 9th March, 2018
SINGAPORE
https://www.isirv.org/site/

November
 
Hu X, Li X, Hu C, Qin L, He R, Luo L, Tang W, Feng J. Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses. Sci Rep.;7(1):15207.
 
Homaira N, Briggs N, Pardy C, Hanly M, Oei JL, Hilder L, Bajuk B, Lui K, Rawlinson W, Snelling T, Jaffe A. Association between respiratory syncytial viral disease and the subsequent risk of the first episode of severe asthma in different subgroups of high-risk Australian children: a whole-of-population-based cohort study. BMJ Open.;7(11):e017936. 
 
Li H, Callahan C, Citron M, Wen Z, Touch S, Monslow MA, Cox KS, DiStefano DJ, Vora KA, Bett A, Espeseth A. Respiratory syncytial virus elicits enriched CD8+ T lymphocyte responses in lung compared with blood in African green monkeys.
PLoS One.;12(11):e0187642. 
 
He L, Fan F, Hou X, Wu H, Wang J, Xu H, Sun Y. 4(3H)-Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG-1 pathway in RAW264.7 cell. Int Immunopharmacol.;52:245-252.
 
Tripp RA, Power UF, Openshaw PJM, Kauvar LM. Respiratory Syncytial Virus (RSV): Targeting the G Protein Provides a New Approach for an Old Problem. J Virol., in press.
 
Eichinger KM, Kosanovich JL, Empey KM. Localization of the T-cell response to RSV infection is altered in infant mice. Pediatr Pulmonol., in press.
 
Goldstein E, Nguyen HH, Liu P, Viboud C, Steiner CA, Worby CJ, Lipsitch M. On the relative role of different age groups during epidemics associated with respiratory syncytial virus. J Infect Dis., in press.
 
Arbefeville S, Thonen-Kerr E, Ferrieri P. Prospective and Retrospective Evaluation of the Performance of the FDA-Approved Cepheid Xpert Flu/RSV XC Assay. Lab Med.;48(4):e53-e56.
 
Lê VB, Riteau B, Alessi MC, Couture C, Jandrot-Perrus M, Rhéaume C, Hamelin MÈ, Boivin G. Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections. Br J Pharmacol., in press.
 
Lee SR, Kwok KL, Ng DKK, Hon KL. Palivizumab for Infants < 29 Weeks in Hong Kong without a Clear-Cut Season for Respiratory Syncytial Virus Infection-A Cost-Effectiveness Analysis. J Trop Pediatr., in press.
 
Cowling BJ, Xu C, Tang F, Zhang J, Shen J, Havers F, Wendladt R, Leung NH, Greene C, Iuliano AD, Shifflett P, Song Y, Zhang R, Kim L, Chen Y, Chu DK, Zhu H, Shu Y, Yu H, Thompson MG; CARES investigators. Cohort profile: the China Ageing REespiratory infections Study (CARES), a prospective cohort study in older adults in Eastern China. BMJ Open.;7(10):e017503.
 
Lee JY, Chang J. Recombinant baculovirus-based vaccine expressing M2 protein induces protective CD8+ T-cell immunity against respiratory syncytial virus infection. J Microbiol.;55(11):900-908.
 
Sendi P, Egli A, Dangel M, Frei R, Tschudin-Sutter S, Widmer AF. Respiratory Syncytial Virus Infection Control Challenges with a Novel Polymerase Chain Reaction Assay in a Tertiary Medical Center. Infect Control Hosp Epidemiol.;38(11):1291-1297
 
Malosh RE, Martin ET, Callear AP, Petrie JG, Lauring AS, Lamerato L, Fry AM, Ferdinands J, Flannery B, Monto AS. Respiratory syncytial virus hospitalization in middle-aged and older adults. J Clin Virol.;96:37-43.
 
Seo KH, Bae DJ, Kim JN, Lee HS, Kim YH, Park JS, Kim MS, Chang HS, Son JH, Baek DG, Lee JS, Park CS. Prevalence of Respiratory Viral Infections in Korean Adult Asthmatics With Acute Exacerbations: Comparison With Those With Stable State. Allergy Asthma Immunol Res.;9(6):491-498.
 
October
 
Thongpan I, Mauleekoonphairoj J, Vichiwattana P, Korkong S, Wasitthankasem R, Vongpunsawad S, Poovorawan Y. Respiratory syncytial virus genotypes NA1, ON1, and BA9 are prevalent in Thailand, 2012-2015. PeerJ.;5:e3970. 
 
Moreira LP, Watanabe ASA, Camargo CN, Melchior TB, Granato C, Bellei N. Respiratory syncytial virus evaluation among asymptomatic and symptomatic subjects in a university hospital in Sao Paulo, Brazil in the period of 2009 to 2013. Influenza Other Respir Viruses., in press.
 
Hogan AB, Campbell PT, Blyth CC, Lim FJ, Fathima P, Davis S, Moore HC, Glass K. Potential impact of a maternal vaccine for RSV: A mathematical modelling study. Vaccine.;35(45):6172-6179. 
 
Altman MC, Reeves SR, Parker AR, Whalen E, Misura KMS, Barrow KA, James RG, Hallstrand TS, Ziegler SF, Debley JS. Interferon response to RSV by bronchial epithelium from children with asthma is inversely correlated with pulmonary function. J Allergy Clin Immunol., in press. 
 
Sastry M, Zhang B, Chen M, Joyce MG, Kong WP, Chuang GY, Ko K, Kumar A, Silacci C, Thom M, Salazar AM, Corti D, Lanzavecchia A, Taylor G, Mascola JR, Graham BS, Kwong PD. Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus. PLoS One.;12(10):e0186854. 
 
Yang XX, Li CM, Li YF, Wang J, Huang CZ. Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection. Nanoscale.;9(41):16086-16092.
 
Komaravelli N, Ansar M, Garofalo RP, Casola A. Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein - ring finger protein 4 dependent pathway. Free Radic Biol Med.;113:494-504.
 
Steff AM, Monroe J, Friedrich K, Chandramouli S, Nguyen TL, Tian S, Vandepaer S, Toussaint JF, Carfi A. Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV.
Nat Commun.;8(1):1085.
 
Shambaugh C, Azshirvani S, Yu L, Pache J, Lambert SL, Zuo F, Esser MT. Development of a High-Throughput Respiratory Syncytial Virus Fluorescent Foci-Based Microneutralization Assay. Clin Vaccine Immunol., in press.
 
Ward C, Maselko M, Lupfer C, Prescott M, Pastey MK. Interaction of the Human Respiratory Syncytial Virus matrix protein with cellular adaptor protein complex 3 plays a critical role in trafficking. PLoS One.;12(10):e0184629. 
 
Park JS, Kim YH, Kwon E, Callaway Z, Fujisawa T, Kim CK. Comparison of nasal cytokine profiles of human metapneumovirus and respiratory syncytial virus. Asia Pac Allergy.;7(4):206-212.
 
Rossey I, McLellan JS, Saelens X, Schepens B. Clinical Potential of Prefusion RSV F-specific Antibodies. Trends Microbiol., in press.
 
Rodriguez-Fernandez R, Tapia LI, Yang CF, Torres JP, Chavez-Bueno S, Garcia C, Jaramillo LM, Moore-Clingenpeel M, Jafri HS, Peeples ME, Piedra PA, Ramilo O, Mejias A. Respiratory Syncytial Virus Genotypes, Host Immune Profiles and Disease Severity in Young Children Hospitalized with Bronchiolitis. J Infect Dis., in press.  
 
Sanchez-Luna M, Burgos-Pol R, Oyagüez I, Figueras-Aloy J, Sánchez-Solís M, Martinón-Torres F, Carbonell-Estrany X. Cost-utility analysis of Palivizumab for Respiratory Syncytial Virus infection prophylaxis in preterm infants: update based on the clinical evidence in Spain. BMC Infect Dis.;17(1):687.
 
Hägglund S, Blodörn K, Näslund K¹, Vargmar K, Lind SB, Mi J, Araínga M, Riffault S, Taylor G, Pringle J, Valarcher JF. Proteome analysis of bronchoalveolar lavage from calves infected with bovine respiratory syncytial virus-Insights in pathogenesis and perspectives for new treatments. PLoS One.;12(10):e0186594.
 
Wasserman RL, Greener BN, Mond J. RI-002, an intravenous immunoglobulin containing high titer neutralizing antibody to RSV and other respiratory viruses for use in primary immunodeficiency disease and other immune compromised populations. Expert Rev Clin Immunol.;13(12):1107-1119.
 
Cohen C, Walaza S, Treurnicht FK, McMorrow M, Madhi SA, McAnerney JM, Tempia S. In- and Out-of-hospital Mortality Associated with Seasonal and Pandemic Influenza and Respiratory Syncytial Virus in South Africa, 2009-2013. Clin Infect Dis., in press.
 
Tahamtan A, Samieipoor Y, Nayeri FS, Rahbarimanesh AA, Izadi A, Rashidi-Nezhad A, Tavakoli-Yaraki M, Farahmand M, Bont L, Shokri F, Mokhatri-Azad T, Salimi V. Effects of cannabinoid receptor type 2 in respiratory syncytial virus infection in human subjects and mice. Virulence., in press.
 
Kim YI, Pareek R, Murphy R, Harrison L, Farrell E, Cook R, DeVincenzo J. The antiviral effects of RSV fusion inhibitor, MDT-637, on clinical isolates, vs its achievable concentrations in the human respiratory tract and comparison to ribavirin. Influenza Other Respir Viruses., in press. 
 
DePorre A, Williams DD, Schuster J, Newland J, Bartlett J, Selvarangan R, Mann K, McCulloh R. Evaluating the Impact of Implementing a Clinical Practice Guideline for Febrile Infants With Positive Respiratory Syncytial Virus or Enterovirus Testing. Hosp Pediatr.;7(10):587-594. 
 
Park E, Park PH, Huh JW, Yun HJ, Lee HK, Yoon MH, Lee S, Ko G. Molecular and clinical characterization of human respiratory syncytial virus in South Korea between 2009 and 2014. Epidemiol Infect., in press.
 
Huang Y, Hua J, Wang D, Chen L, Zhang J, Zhu H, Tian J, Zhang T, Zhao G. Risk factors of respiratory syncytial virus infection among pediatric influenza-like illness and severe acute respiratory infections in Suzhou, China. J Med Virol., in press.
 
van Erp EA, van Kasteren PB, Guichelaar T, Ahout IML, de Haan CAM, Luytjes W, Ferwerda G, Wicht O. In Vitro Enhancement of Respiratory Syncytial Virus Infection by Maternal Antibodies Does Not Explain Disease Severity in Infants. J Virol.;91(21).
 
Long XR, Xie J, Li W, Zhao KT, Xie XH, Wang LJ, Ren L, Liu EM, Deng Y. [Effect of interferon-γ on airway inflammation following respiratory syncytial virus reinfection in mice]. Zhonghua Er Ke Za Zhi.;55(10):760-765. [Article in Chinese; Abstract available in Chinese from the publisher]
 
Saraya T, Kimura H, Kurai D, Ishii H, Takizawa H. The molecular epidemiology of respiratory viruses associated with asthma attacks: A single-center observational study in Japan. Medicine (Baltimore).;96(42):e8204. 
 
Jartti T, Gern JE. Role of viral infections in the development and exacerbation of asthma in children. J Allergy Clin Immunol.;140(4):895-906.
 
Scheltema NM, Gentile A, Lucion F, Nokes DJ, Munywoki PK, Madhi SA, Groome MJ, Cohen C, Moyes J, Thorburn K, Thamthitiwat S, Oshitani H, Lupisan SP, Gordon A, Sánchez JF, O'Brien KL; PERCH Study Group, Gessner BD, Sutanto A, Mejias A, Ramilo O, Khuri-Bulos N, Halasa N, de-Paris F, Pires MR, Spaeder MC, Paes BA, Simões EAF, Leung TF, da Costa Oliveira MT, de Freitas Lázaro Emediato CC, Bassat Q, Butt W, Chi H, Aamir UB, Ali A, Lucero MG, Fasce RA, Lopez O, Rath BA, Polack FP, Papenburg J, Roglić S, Ito H, Goka EA, Grobbee DE, Nair H, Bont LJ.
Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series. Lancet Glob Health.;5(10):e984-e991.
 
Chu HY, Tielsch J, Katz J, Magaret AS, Khatry S, LeClerq SC, Shrestha L, Kuypers J, Steinhoff MC, Englund JA. Transplacental transfer of maternal respiratory syncytial virus (RSV) antibody and protection against RSV disease in infants in rural Nepal. J Clin Virol.;95:90-95.
 
Xiang Z, Liang Z, Yanfeng H, Leitao K. Persistence of RSV promotes proliferation and epithelial-mesenchymal transition of bronchial epithelial cells through Nodal signaling. J Med Microbiol.;66(10):1499-1505.
 
McMullen P, Boonlayangoor S, Charnot-Katsikas A, Beavis KG, Tesic V. The performance of Luminex ARIES® Flu A/B & RSV and Cepheid Xpert® Flu/RSV XC for the detection of influenza A, influenza B, and respiratory syncytial virus in prospective patient samples. J Clin Virol.;95:84-85.
  
September
 
Rajan D, Chinnadurai R, Keefe EO, Boyoglu-Barnum S, Todd SO, Hartert TV, Galipeau J, Anderson LJ. Protective role of Indoleamine 2,3 dioxygenase in Respiratory Syncytial Virus associated immune response in airway epithelial cells. Virology.;512:144-150.
 
Harris D, Cooper E, Vanner C, Mermel L. Respiratory viral testing in laboratories serving acute care hospitals in Rhode Island. R I Med J (2013).;100(9):29-30.
 
Goriacko P, Saiman L, Zachariah P. Antibiotic Use in Hospitalized Children with Respiratory Viruses Detected by Multiplex Polymerase Chain Reaction. Pediatr Infect Dis J., in press.
 
Levitz R, Gao Y, Dozmorov I, Song R, Wakeland EK, Kahn JS. Distinct patterns of innate immune activation by clinical isolates of respiratory syncytial virus. PLoS One.;12(9):e0184318.
 
Das S, Raundhal M, Chen J, Oriss TB, Huff R, Williams JV, Ray A, Ray P. Respiratory syncytial virus infection of newborn CX3CR1-deficent mice induces a pathogenic pulmonary innate immune response. JCI Insight.;2(17).
 
Smith TRF, Schultheis K, Broderick KE. Nucleic acid-based vaccines targeting respiratory syncytial virus: delivering the goods. Hum Vaccin Immunother. 2017 Sep 7:0., in press.
 
Jaberolansar N, Chappell KJ, Watterson D, Bermingham IM, Toth I, Young PR, Skwarczynski M. Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein. Sci Rep.;7(1):11130.
 
Kashiwagi T, Okada Y, Nomoto K. Palivizumab Prophylaxis Against Respiratory Syncytial Virus Infection in Children with Immunocompromised Conditions or Down Syndrome: A Multicenter, Post-Marketing Surveillance in Japan. Paediatr Drugs., in press.
 
Kim L, Rha B, Abramson JS, Anderson LJ, Byington CL, Chen GL, DeVincenzo J, Edwards KM, Englund JA, Falsey AR, Griffin MR, Karron RA, Martin KG, Meissner HC, Munoz FM, Pavia AT, Piedra PA, Schaffner W, Simões EAF, Singleton R, Talbot HK, Walsh EE, Zucker JR, Gerber SI. Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines. Clin Infect Dis.;65(6):1020-1025.
 
Chow JW, Chicella MF, Christensen AM, Moneymaker CS, Harrington J, Dice JE. Improving Palivizumab Compliance rough a Pharmacist-Managed RSV Prevention Clinic. J Pediatr Pharmacol Ther.;22(5):338-343. 
 
Mehedi M, Smelkinson M, Kabat J, Ganesan S, Collins PL, Buchholz UJ. Multicolor Stimulated Emission Depletion (STED) Microscopy to Generate High-resolution Images of Respiratory Syncytial Virus Particles and Infected Cells. Bio Protoc. 2017 Sep 5;7(17).
 
Do LAH, Pellet J, van Doorn HR, Tran AT, Nguyen BH, Tran TTL, Tran QH, Vo QB, Tran Dac NA, Trinh HN, Nguyen TTH, Le Binh BT, Nguyen HMK, Nguyen MT, Thai QT, Vo TV, Ngo NQM, Dang TKH, Cao NH, Tran TV, Ho LV, De Meulder B, Auffray C, Hofstra JJ, Farrar J, Bryant JE, de Jong M, Hibberd ML. Host Transcription Profile In Nasal Epithelium And Whole Blood of Hospitalised Children under two years of age with Respiratory Syncytial Virus Infection. J Infect Dis., in press.
 
Capella C, Chaiwatpongsakorn S, Gorrell E, Risch ZA, Ye F, Mertz SE, Johnson SM, Moore-Clingenpeel M, Ramilo O, Mejias A, Peeples ME. Prefusion F, postfusion F, G antibodies and disease severity in infants and young children with acute respiratory syncytial virus infection. J Infect Dis., in press.
 
Korsun N, Angelova S, Tzotcheva I, Georgieva I, Lazova S, Parina S, Alexiev I, Perenovska P. Prevalence and genetic characterisation of respiratory syncytial viruses circulating in Bulgaria during the 2014/15 and 2015/16 winter seasons. Pathog Glob Health., in press.
 
Elawar F, Griffiths CD, Zhu D, Bilawchuk LM, Jensen LD, Forss L, Tang J, Hazes B, Drews SJ, Marchant DJ. A Virological and Phylogenetic Analysis of the Emergence of New Clades of Respiratory Syncytial Virus. Sci Rep.;7(1):12232. 
 
Falloon J, Yu J, Esser MT, Villafana T, Yu L, Dubovsky F, Takas T, Levin MJ, Falsey AR. An Adjuvanted, Postfusion F Protein-Based Vaccine Did Not Prevent Respiratory Syncytial Virus Illness in Older Adults. J Infect Dis., in press.
 
Raguz MJ, Brzica J, Grgic I. Palivizumab: The Effects of Prophylactic Immunization on the Occurrence of Infections Caused by the Respiratory Syncytial Virus. Klin Padiatr.;229(5):281-285. 
 
Vanover D, Smith DV, Blanchard EL, Alonas E, Kirschman JL, Lifland AW, Zurla C, Santangelo PJ. RSV glycoprotein and genomic RNA dynamics reveal filament assembly prior to the plasma membrane. Nat Commun.;8(1):667.
 
Mastrangelo P, Norris MJ, Duan W, Barrett EG, Moraes TJ, Hegele RG. Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities. Vaccines (Basel).;5(3).
 
Gao J, Li Y, Wang Q, Ma X, Zhang Y. Oxysophocarpine inhibits lung injury induced by respiratory syncytial virus. Am J Transl Res.;9(9):4083-4093.
 
Xie J, Long X, Gao L, Chen S, Zhao K, Li W, Zhou N, Zang N, Deng Y, Ren L, Wang L, Luo Z, Tu W, Zhao X, Fu Z, Xie X, Liu E. The NS1 protein of Respiratory syncytial virus blocks glucocorticoid receptor nuclear translocation by targeting IPO13 may account for glucocorticoid insensitive. J Infect Dis., in press. 
 
Luo Q, Guo X, Peng S, Luo W, Tian F, Yu P, Zou Y. The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children. Int J Immunogenet., in press.
Rincheval V, Lelek M, Gault E, Bouillier C, Sitterlin D, Blouquit-Laye S, Galloux M, Zimmer C, Eleouet JF, Rameix-Welti MA. Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus. Nat Commun.;8(1):563.
 
Brealey JC, Chappell KJ, Galbraith S, Fantino E, Gaydon J, Tozer S, Young PR, Holt PG, Sly PD. Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children. Respirology., in press.
 
Hashimoto K, Hosoya M. Neutralizing epitopes of RSV and palivizumab resistance in Japan. Fukushima J Med Sci., in press.
 
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This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement Nº 116019. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.